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業績のご紹介。Publications and presentations。

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受賞- Prize -

平成29年度『日本リウマチ学会 学会賞』桑名正隆 大学院教授

日本リウマチ学会 学会賞 桑名正隆

桑名正隆教授が表記の賞を受賞し、4月20日第61回日本リウマチ学会総会・学術集会(福岡)にて受賞講演を行いました。 本賞は、日本におけるリウマチ学に関する臨床的または基礎的研究の振興並びにリウマチ学の発展に顕著な貢献のあった者を顕彰するものです。

論文- Publications -

原著- Original articles -

  1. Detection of circulating B cells producing anti-GPIb autoantibodies in patients with immune thrombocytopenia.

    *Kuwana M, Okazaki Y, and Ikeda Y.
    PLoS One. 2014; 9(1): e86943.

  2. Serum adhesion molecule levels as prognostic markers in patients with early systemic sclerosis: a multicentre, prospective, observational study.

    Hasegawa M, Asano Y, Endo H, Fujimoto M, Goto D, Ihn H, Inoue K, Ishikawa O, Kawaguchi Y, Kuwana M, Ogawa F, Takahashi H, Tanaka S, Sato S, and Takehara K.
    PLoS One. 2014; 9(2): e88150.

  3. Cardiac involvements in myasthenia gravis associated with anti-Kv1.4 antibodies.

    Suzuki S, Baba A, Kaida K, Utsugisawa K, Kita Y, Tsugawa J, Ogawa G, Nagane Y, Kuwana M, and Suzuki N.
    Eur. J. Neurol. 2014; 21(2): 223-230.

  4. Autoantibodies to RuvBL1 and RuvBL2: a novel systemic sclerosis-related antibody associated with diffuse cutaneous and skeletal muscle involvement.

    Kaji K, Noreen F, Medsger TA Jr, Satoh T, Hoshino K, Hamaguchi Y, Hasegawa M, Lucus M, Schnure A, Ogawa F, Sato S, Takehara K, Fujimoto M, and *Kuwana M.
    Arthritis Care Res. 2014; 66(4): 575-584.

  5. Reconciling healthcare professional and patient perspectives in the development of disease activity and response criteria in connective tissue disease-related interstitial lung diseases.

    Saketkoo LA, Mittoo S, Frankel S, Lesage D, Sarver C, Phillips K, Strand V, Matteson EL, OMERACT Connective Tissue Disease–Interstitial Lung Diseases Working Group, and Delphi Process Collaborators.
    J. Rheumatol. 2014; 41(4): 792-798.

  6. Connective tissue disease related interstitial lung diseases and idiopathic pulmonary fibrosis: provisional core sets of domains and instruments for use in clinical trials.

    Saketkoo LA, Mittoo S, Huscher D, Khanna D, Dellaripa PF, Distler O, Flaherty KR, Frankel S, Oddis CV, Denton CP, Fischer A, Kowal-Bielecka OM, Lesage D, Merkel PA, Phillips K, Pittrow D, Swigris J, Antoniou K, Baughman RP, Castelino FV, Christmann RB, Christopher-Stine L, Collard HR, Cottin V, Danoff S, Highland KB, Hummers L, Shah AA, Kim DS, Lynch DA, Miller FW, Proudman SM, Richeldi L, Ryu JH, Sandorfi N, Sarver C, Wells AU, Strand V, Matteson EL, Brown KK, Seibold JR and Dephi co-authors.
    Thorax. 2014; 69(5): 436-444.

  7. A single nucleotide polymorphism of TRAF1 predicts the clinical response to anti-TNF treatment in Japanese patients with rheumatoid arthritis.

    Nishimoto T, Seta N, Anan R, Yamamoto T, Kaneko Y, Takeuchi T, and Kuwana M.
    Clin. Exp. Rheumatol. 2014; 32(2): 211-217.

  8. Impaired in vivo neovascularization capacity of endothelial progenitor cells in patients with systemic sclerosis.

    *Kuwana M, and Okazaki Y.
    Arthritis Rheumatol. 2014; 66(5): 1300-1305.

  9. IgG4-related disease in pulmonary arterial hypertension on long-term epoprostenol treatment.

    Shirai Y, Tamura Y, Yasuoka H, Satoh T, and *Kuwana M.
    Eur. Respir. J. 2014; 43(5): 1516-1519.

  10. Discordance in global assessments between patient and estimator in patients with newly diagnosed rheumatoid arthritis: associations with progressive joint destruction and functional disorder.

    Kaneko Y, Kuwana M, Kondo H, and Takeuchi T.
    J. Rheumatol. 2014; 41(6): 1061-1066.

  11. Distinct arthropathies in patients with anti-aminoacyl tRNA synthetase antibodies: usefulness of autoantibody profiles in classifying patients.

    Kaneko Y, Hanaoka H, Hirakata M, Takeuchi T, and Kuwana M.
    Rheumatology. 2014; 53(6): 1120-1124.

  12. Lifestyle and other related factors for the development of mixed connective tissue disease among Japanese females in comparison with systemic lupus erythematosus.

    Washio M, Fujii T, Kuwana M, Kawaguchi Y, Mimori A, Horiuchi T, Tada Y, Takahashi H, Mimori T, and Japan MCTD study group.
    Mod. Rheumatol. 2014; 24(5): 788-792.

  13. Clinical and histological findings associated with autoantibodies detected by RNA immunoprecipitation in inflammatory myopthies.

    Suzuki S, Yonekawa T, Kuwana M, Hayashi YK, Okazaki Y, Kawaguchi Y, Suzuki N, and Nishino I.
    J. Neuroimmunol. 2014; 274(1-2): 202-208.

  14. Recurrent right atrial thrombosis due to Behçet’s disease.

    Kuno T, Tamura Y, Kimura K, Ono T, Murata M, Kuwana M, Satoh T, and Fukuda K.
    Can. J. Cardiol. 2014; 30(10): 1250.e1-3.

  15. Fatal case of clinically amyopathic dermatomyositis: cotton-wool spots as a sign of an aggressive subtype of dermatomyositis.

    Ito A, Nakamura Y, Saito K, Sho Y, Ishikawa K, Shimada H, Hatano Y, Okamoto O, Haranaka M, Ishii K, Nakamuro T, Kimoto K, Kuwana M, Hamaguchi Y, and Fujiwara S.
    J. Dermatol. 2014; 41(10): 943-944.

  16. A rare association of Fabry’s disease and granulomatosis with polyangiitis: a potential pathogenic link.

    Hanaoka H, Hashiguchi A, Konishi K, Ishii T, and Kuwana M.
    BMC Nephrol. 2014; 15(1): 157.

  17. Induction of immune tolerance to platelet antigen by short-term thrombopoietin treatment in a mouse model of immune thrombocytopenia.

    Nishimoto T, Numajiri M, Nakazaki H, Okazaki Y, and *Kuwana M.
    Int. J. Hematol. 2014;100(4): 341-344.

  18. Comparison of radioimmunoprecipitation versus antigen-specific assays for identification of myositis specific autoantibodies in dermatomyositis patients.

    Kang EH, Kuwana M, Okazaki Y, Lee EY, Lee YJ, Lee EB, and Song YW.
    Mod. Rheumatol. 2014; 26(6): 945-948.

  19. Analysis of various factors on the relapse of acute neurological attacks in Behcet's disease.

    Hirohata S, Kikuchi H, Sawada T, Nagafuchi H, Kuwana M, Takeno M, and Ishigatsubo Y.
    Mod. Rheumatol. 2014; 24(6): 961-965.

  20. Cytokine profiles in polymyositis and dermatomyositis complicated with rapidly progressive or chronic interstitial lung disease.

    Gono T, Kaneko H, Kawaguchi Y, Hanaoka M, Kataoka S, Kuwana M, Takagi K, Ichida H, Katsumata Y, Ota Y, Kawasumi H, and Yamanaka H.
    Rheumatology. 2014; 53(12): 2196-2203.

  21. Tocilizumab is clinically, functionally, and radiographically effective and safe either with or without low-dose methotrexate in active rheumatoid arthritis patients with inadequate responses to DMARDs and/or TNF inhibitors: A single-center retrospective cohort study (KEIO-TCZ study) at week 52.

    Izumi K , Kaneko Y, Yasuoka H, Seta N, Kameda H, Kuwana M, Takeuchi T.
    Mod. Rheumatol. In press.

  22. Serum interferon-α is a useful biomarker in patients with anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis.

    Horai Y, Koga T, Fujikawa K, Takatani A, Nishino A, Nakashima Y, Suzuki T, Kawashiri S, Iwamoto N, Ichinose K, Tamai M, Nakamura H, Ida H, Kakugawa T, Sakamoto N, Ishimatsu Y, Mukae H, Hamaguchi Y, Fujimoto M, Kuwana M, Origuchi T, Kohno S, and Kawakami A.
    Mod. Rheumatol. In press.

  23. Polychondritis presenting with oculomotor and abducens nerve palsies as the initial manifestation.

    Akiyama M, Kaneko Y, Hanaoka H, Kuwana M, and Takeuchi T.
    Mod. Rheumatol. In press.

  24. Effects of the endothelin receptor antagonist bosentan on hemodynamics and exercise capacity in Japanese patients with mildly symptomatic pulmonary arterial hypertension.

    Hatano M, Yamada H, Fukuda K, Yoshioka K, Funauchi M, Kuwana M, Sata M, Taniguchi M, Nakanishi N, Saito T, Saji T, and Sasayama S.
    Heart Vessels. In press.

  25. Cinical and laboratory features of fetal rapidly progressive interstitial lung diseases associated with juvenile dermatomyositis.

    Kobayashi N, Takezaki S, Kobayashi I, Iwata N, Mori M, Nagai K, Nakano N, Miyoshi M, Kinjo N, Murata T, Masunaga K, Umebayashi H, Imagawa T, Agematsu K, Sato S, Kuwana M, Yamada M, Yokota S, Koike K, and Ariga T.
    Rheumatology. In press.

  26. An unusual association between focal segmental sclerosis and lupus nephritis: a distinctive concept from lupus podocytopathy?

    Hanaoka H, Hashiguchi A, Konishi K, Kuwana M, and Takeuchi T.
    CEN Case Reports. In press.

  27. Elevated pentraxin 3 in systemic sclerosis: associations with vascular manifestations and defective vasculogenesis.

    Shirai Y, Okazaki Y, Inoue Y, Tamura Y, Yasuoka H, Takeuchi T, and *Kuwana M.
    Arthritis Rheumatol. In press.

    Supplementary data(PDF:1.67MB, English)

  28. Acute kidney injury due to renal sarcoidosis during etanercept therapy: a case report and a literature review.

    Akiyama M, Kaneko Y, Hanaoka H, Kuwana M, and Takeuchi T.
    Intern. Med. In press.

  29. Clinical and immunological predictors of scleroderma renal crisis for Japanese systemic sclerosis patients with anti-RNA polymerase III antibody.

    Hamaguchi Y, Kodera M, Matsushita T, Usuda T, Kuwana M, Takehara K, and Fujimoto M.
    Arthritis Rheumatol. In press.

総説- Reviews -

  1. Helicobacter pylori-associated immune thrombocytopenia: clinical features and pathogenic mechanisms.

    *Kuwana M.
    World J Gastroenterol. 2014; 20(3): 714-723.

  2. How to detect early stage rheumatoid arthritis (RA) in persons undergoing ningen dock (Health evaluation and promotion).

    Kaburaki J, and Kuwana M.
    Ningen Dock Int. 2014; 1(1): 24-33.

  3. Dysregulated negative immune regulators in immune thrombocytopenia.

    *Kuwana M.
    ISBT Sci. Ser. In press.

国際学会発表- Presentations -

特別講演- Invited lectures -

  1. Potential roles of circulating endothelial progenitor cells and monocytes in the pathogenesis of systemic sclerosis.

    Kuwana M
    International Network of Scleroderma Clinical Care and Research (Shanghai). 2014. 3.

  2. Clinical associations of autoantibodies in SSc.

    Kuwana M
    The 4th Symposium of International Network of Scleroderma Clinical Care and Research (Shanghai). 2014. 3.

  3. Current topics of Behçet’s disease in Japan.

    Takeno M
    16th Annual Meeting of the Korean Society for Behçet’s Disease (Seoul). 2015.10.

一般演題- Abstructs -

  1. Complex pathophysiology of pulmonary hypertension associated with systemic sclerosis: merits and demerits of aggressive treatment with pulmonary vasodilators.

    Kuwana M
    3rd Systemic Sclerosis World Congress (Rome). 2014. 2.

  2. Excessive fibrosis and pulmonary vascular remodeling in Fra-1 transgenic mice.

    Yasuoka H, Okazaki Y, Tam A, Tamura Y, Takada I, Matsuo K, Takeuchi T, Kuwana M
    3rd Systemic Sclerosis World Congress (Rome). 2014. 2.

  3. Validation of preliminary algorithm for differential diagnosis of thrombocytopenia in patients with systemic lupus erythematosus.

    Kuwana M, Okazaki Y, Hanaoka H, Takeuchi T
    The European League Against Rheumatism 2014 (Paris). 2014. 6.

  4. Elevated Pentraxin 3 in Patients with Systemic Sclerosis: Associations with Vascular Manifestations and Defective Vasculogenesis.

    Shirai Y, Okazaki Y, Inoue Y, Tamura Y, Yasuoka H, Takeuchi T, and Kuwana M
    The 78th Annual Scientific Meeting of American College of Rheumatology (Boston). 2014. 11

  5. Takayasu Arteritis and Ulcerative Colitis-High Concurrence Raito and Genetic Overlap.

    Terao C, Matsumura T, Yoshifuji H, Kirino Y, Maejima Y, Nakaoka Y, Takahashi M, Amiya E, Tamura N, Nakajima T, Origuchi T, Horita T, Matsukura M, Kochi Y, Ogimoto A, Yamamoto M, Takahashi H, Nakayamada S, Saito K, Wada Y, Narita I, Kawaguchi Y, Yamanaka H, Ohmura K, Atsumi T, Tanemoto K, Miyata T, Kuwana M, Komuro I, Tabara Y, Ueda A, Isobe M, Mimori T, and Matsuda F
    The 78th Annual Scientific Meeting of American College of Rheumatology (Boston). 2014. 11

  6. Association of Hand MRI Findings with the Level of Plasma Cytokines in Patients with Newly Diagnosed Rheumatoid Arthritis.

    Kondo Y, Kaneko Y, Sugiura H, Matsumoto S, Nishina N, Kuwana M, Jinzaki M and Takeuchi T
    The 78th Annual Scientific Meeting of American College of Rheumatology (Boston). 2014. 11

  7. A New Multianalyte Assay for Detection of Dermatomyositis-Specific Autoantibodies Undetectable By Commercially Available Immunoassays.

    Kuwana M, Okazaki Y and Takeuchi T
    The 78th Annual Scientific Meeting of American College of Rheumatology (Boston). 2014. 11

  8. Enzyme-Linked Immunosorbent Assays for Detection of Anti-Transcriptional Intermediary Factor-1 Gamma and Anti-Mi-2 Autoantibodies in Dermatomyosits: Utility and Crossreactivity.

    Fujimoto M, Murakami A, Kurei S, Kuwajima A, Fujisawa Y, Kawakami A, Mishima M, Sato S, Seishima M, Suda T, Mimori T, Takehara K and Kuwana M
    The 78th Annual Scientific Meeting of American College of Rheumatology (Boston). 2014. 11

  9. A Multi-Center Study for Validation of a New Assay for Anti-Melanoma Differentiation-Associated Gene 5 (MDA5) Autoantibody.

    Sato S, Murakami A, Kuwajima A, Takehara K, Mimori T, Kawakami A, Mishima M, Suda T, Seishima M, Fujimoto M and Kuwana M
    The 78th Annual Scientific Meeting of American College of Rheumatology (Boston). 2014. 11

  10. Anti-MDA5 is Associated with Rapidly-Progresstive Interstitial Lung Disease and Poor Survival in U.S. Patients with Amyopathic and Myopathic Dermatomyositis.

    Moghadam-K S, Oddis C.V, Sato S, Kuwana M and Aggarwal R
    The 78th Annual Scientific Meeting of American College of Rheumatology (Boston). 2014. 11

  11. Up-Regulated Expression of CXCR4 on Circulating B Cells in Patients with Systemic Lupus Erythematosus.

    Hanaoka H, Okazaki Y, Hashiguchi A, Yasuoka H, Takeuchi T and Kuwana M
    The 78th Annual Scientific Meeting of American College of Rheumatology (Boston). 2014. 11

  12. Long-Term Outcome of Chronic Progressive Neurological Manifestations in Behcet’s Disease.

    Hirohata S, Kikuchi H, Sawada T, Nagafuchi H, Kuwana M, Takeno M and Ishigatsubo Y
    The 78th Annual Scientific Meeting of American College of Rheumatology (Boston). 2014. 11

  13. Anti-Fibrotic Effects of a Newly Discovered HGF Receptor Carboxy-Terminal Fragment in Systemic Sclerosis.

    Shirai Y, Atanelishvili I, Akter T, Silver RM and Bogatkevich GS
    The 78th Annual Scientific Meeting of American College of Rheumatology (Boston). 2014. 11

  14. IQGAP1 Enhances Contractility of Scleroderma Lung Fibroblasts and Promotes Bleomycin-Induced Pulmonary Fibrosis.

    Akter T, Atanelishvili I, Shirai Y, Nelson SP, Garcia-Martos A, Morinelli TA, Silver RM and Bogatkevich GS
    The 78th Annual Scientific Meeting of American College of Rheumatology (Boston). 2014. 11

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